Furfuryl Alcohol → HCID 86584185, compound

Participants

Reaction Steps

8-(3,5-Bis-trifluoromethyl-benzoyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione (200 mg, 0.41 mmol) was dissolved in dry dioxane (10 mL) and triphenylphosphin (145 mg, 0.54 mmol), furfuryl alcohol (53.1 mg, 0.54 mmol) and diethylazodicarboxylate (40% in toluene, 0.54 mmol) were added sequentially and stirred at room temperature overnight. The solvent was evaporated and the residue was purified by chromatography on silica gel (dichloromethane) to yield the desired product (143 mg, 61%), MS: m/e=566.1 (M+H+).

Provenance & Evidence