(S)-5-(Hydroxymethyl)-2-pyrrolidinone → HCID 22898533, compound

HRID 1018605Notes

Reaction equation

HRID 1018605 reaction equation
[F:1][C:2]([F:34])([F:33])[C:3]1[CH:4]=[C:5]([CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:28]=1)[C:6]([N:8]1[CH2:25][CH2:24][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:14](=[O:22])[NH:13][C:12]2=[O:23])[CH2:10][CH2:9]1)=[O:7].O[CH2:36][C@H:37]1[NH:41][C:40](=[O:42])[CH2:39][CH2:38]1>>[F:34][C:2]([F:1])([F:33])[C:3]1[CH:4]=[C:5]([CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:28]=1)[C:6]([N:8]1[CH2:9][CH2:10][C:11]2([N:15]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[C:14](=[O:22])[N:13]([CH2:36][C@@H:37]3[CH2:38][CH2:39][C:40](=[O:42])[NH:41]3)[C:12]2=[O:23])[CH2:24][CH2:25]1)=[O:7]

Participants

3

Reactant 2

HCID 643511(S)-5-(Hydroxymethyl)-2-pyrrolidinoneHCID 18401669HCID 18401669, compound

Product 1

HCID 22898533HCID 22898533, compound

Procedure

The title compound, MS: m/e=583.1 (M+), was prepared in accordance with the general method of example 121 from 8-(3,5-bis-trifluoromethyl-benzoyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione and (S)-5-(hydroxymethyl)-2-pyrrolidinone.

Sources & evidence

ORD record
ord-ce71eca486a54c61a1ff18793380584b
Source dataset
uspto-grants-2002_11
Patent number
US06482829B2

Reaction notes

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