4-(2-Chloroethyl)morpholine → HCID 18401645, compound

HRID 1018619Notes

Reaction equation

HRID 1018619 reaction equation
[F:1][C:2]([F:34])([F:33])[C:3]1[CH:4]=[C:5]([CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:28]=1)[C:6]([N:8]1[CH2:25][CH2:24][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[C:14](=[O:23])[NH:13][CH2:12]2)[CH2:10][CH2:9]1)=[O:7].Cl[CH2:36][CH2:37][N:38]1[CH2:43][CH2:42][O:41][CH2:40][CH2:39]1>>[F:34][C:2]([F:1])([F:33])[C:3]1[CH:4]=[C:5]([CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:28]=1)[C:6]([N:8]1[CH2:25][CH2:24][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[C:14](=[O:23])[N:13]([CH2:36][CH2:37][N:38]3[CH2:43][CH2:42][O:41][CH2:40][CH2:39]3)[CH2:12]2)[CH2:10][CH2:9]1)=[O:7]

Participants

3

Reactant 2

HCID 767274-(2-Chloroethyl)morpholineHCID 18401720HCID 18401720, compound

Product 1

HCID 18401645HCID 18401645, compound

Procedure

The title compound, MS: m/e=599.1 (M+H+), was prepared in accordance with the general method of example 99 from 8-(3,5-bis-trifluoromethyl-benzoyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-2-one and 4-(chloroethyl)morpholine.

Sources & evidence

ORD record
ord-e449de38f116449c8c597de49b81da07
Source dataset
uspto-grants-2002_11
Patent number
US06482829B2

Reaction notes

Loading…