Acetyl chloride → HCID 18401623, compound

HRID 1018621Notes

Reaction equation

[F:1][C:2]([F:34])([F:33])[C:3]1[CH:4]=[C:5]([CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:28]=1)[C:6]([N:8]1[CH2:25][CH2:24][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[C:14](=[O:23])[NH:13][CH2:12]2)[CH2:10][CH2:9]1)=[O:7].[C:35](Cl)(=[O:37])[CH3:36]>>[C:35]([N:13]1[CH2:12][C:11]2([CH2:24][CH2:25][N:8]([C:6](=[O:7])[C:5]3[CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:28]=[C:3]([C:2]([F:1])([F:33])[F:34])[CH:4]=3)[CH2:9][CH2:10]2)[N:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[C:14]1=[O:23])(=[O:37])[CH3:36]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 18401720HCID 18401720, compound

Product 1

HCID 18401623HCID 18401623, compound

Procedure

The title compound, MS: m/e=528.1 (M+H+), was prepared in accordance with the general method of example 99 from 8-(3,5-bis-trifluoromethyl-benzoyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-2-one and acetyl chloride.

Sources & evidence

ORD record: ord-f2b9ba7ec8c24163898ff008028c64dd
Source dataset: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06482829B2

Reaction notes

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