Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Iodothiophene | HCID 18921 | — |
| Reactant | HCID 54353041 | HCID 54353041 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 54215806 | HCID 54215806 | — |
Reaction Steps
2 g of (S)-2-(ethylsulfonyl-amino)-3-methyl-butyric acid N-[2-(3-methoxy-4-propargyloxy-phenyl)-ethyl]-amide, 2.1 g of 2-iodothiophene and 2 ml of triethylamine are heated to 40° C. in 50 ml of chloroform. 70 mg of bis(triphenylphosphine)palladium(II) chloride and 32 mg of copper(I) iodide are added thereto. The reaction mixture is stirred for one hour at 60° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06482859B1 |
|---|
| Source dataset | uspto-grants-2002_11 |
|---|
| ORD ID | ord-ac43eddc16cb43008ffa85efe97ade7e |
|---|
| Source note | uspto-grants-2002_11 |
|---|
