HCID 12072786, compound → HCID 12072787, compound

Participants

Reaction Steps

To (S)-5-azido-8-cyclohexylmethoxy-2,3,4,5-tetrahydro-benzo[b]oxepine-7-carboxylic acid amide (2.5 g, 5.8 mmol) in EtOAc (20 mL) was added 10% Pd/C (0.25 g). The mixture was hydrogenated at STP for 17 h, filtered though glass, and concentrated to a white solid (1.8 g, 98%). MS [M−H]− 317, m.p. 145-146° C. Optical purity determined by Mosher Amide formation, 55% e.e.

Provenance & Evidence