HCID 70152428, compound → HCID 11299226, compound

Participants

Reaction Steps

A solution of (2S,3S)-3-((benzyloxy)methylamino)-2-(tert-butoxyformamido)butyric acid 9 (2.4 g, 14.8 mmol) in 20 mL methanol was added under nitrogen to a suspension of 10% palladium on charcoal (0.6 g, 25 wt %) in 20 mL methanol in a Parr hydrogenator flask. The mixture was placed on the Parr hydrogenator and hydrogenated at 50 psi for 18 hours. The catalyst was removed by filtration and the filtrate evaporated in vacuo. The residue was then lyophilized, affording 1.55 g of (2S,3S)-3-methylamino-2-(tert-butoxyformamido)butyric acid 10 as a white solid (95% yield).

Provenance & Evidence