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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1018732Generated: October 30, 2026

Trifluoroacetic acid → HCID 131723647, compound

https://huagongshe.com/reaction/1018732

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 131723646HCID 131723646—
SolventDichloromethaneHCID 6344—
ProductHCID 131723647HCID 131723647—

Reaction Steps

Morpholino-Ser(OBn) was prepared from N-Fmoc-Ser(OBn). Esterification of N-Fmoc-Ser(OBn) with isobutylene in the presence of a catalytic amount of H2SO4 afforded N-Fmoc-Ser(OBn)-OtBu. The Fmoc group was removed with piperidine in CH2Cl2 to produce Ser(OBn)-OtBu. Reaction of Ser(OBn)-OtBu with 4-morpholinecarbonyl chloride in pyridine yielded morpholino-Ser(OBn)-OtBu. Morpholino-Ser(OBn)-OtBu was hydrolyzed with TFA in CH2Cl2 to yield morpholine-Ser(OBn).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06482943B1
Source datasetuspto-grants-2002_11
ORD IDord-c344465c63c04a9188529259e5e904bc
Source noteuspto-grants-2002_11