HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thioglycolic Acid → HCID 12056532, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thioglycolic Acid | HCID 1133 | — |
| Reactant | Beta-Nitrostyrene | HCID 7626 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Catalyst | Pyrrolidine | HCID 31268 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 12056532 | HCID 12056532 | 81.3% |
Reaction Steps
A solution of nitrostyrene (10 g, 0.067 mol) in tetrahydrofuran (250 ml) is treated with mercaptoacetic acid (7.4 g, 5.6 ml, 0.08 mol) followed by pyrollidine (3 drops). After stirring for 2 hours the reaction mixture is concentrated onto silica gel and chromatographed, eluting with 4:1, hexanes:ethyl acetate, to give the title product as a solid (13.14 g, 81% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06482962B2 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-a219c65a73c0470995c617f98965a45a |
| Source note | uspto-grants-2002_11 |