Thiosemicarbazide → HCID 3002293, compound

HRID 1018783Notes

Reaction equation

HRID 1018783 reaction equation
[C:1]([NH:4][C:5]1[CH:12]=[CH:11][C:8]([CH:9]=O)=[C:7]([F:13])[CH:6]=1)(=[O:3])[CH3:2].[NH2:14][NH:15][C:16]([NH2:18])=[S:17]>>[C:1]([NH:4][C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[N:14][NH:15][C:16]([NH2:18])=[S:17])=[C:7]([F:13])[CH:6]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 2723789ThiosemicarbazideHCID 10214430HCID 10214430, compound

Product 1

HCID 3002293HCID 3002293, compoundYield 45%

Procedure

4-Acetamido-2-fluorobenzaldehyde 20 then is reacted with thiosemicarbazide to form 4-acetamido-2-fluorobenzaldehyde thiosemicarbazone 17 in 45% yield. An exemplary scheme for this reaction is shown below.

Sources & evidence

ORD record
ord-25b41e7c91e242adaff7b2b218a098dd
Source dataset
uspto-grants-2002_11
Patent number
US06482982B1

Reaction notes

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