反应详情

This compound was prepared via BOP coupling of (S)-3-cyclohexyl-2-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionic acid (prepared in Step A of Example 1; 120 mg; 0.42 mmol) and 2-amino-5-chlorothiazole hydrochloride (90 mg; 0.51 mmol) in a manner similar to that used for the preparation of (S)-3-cyclohexyl-2-(1-oxo-1,3-dihydro-isoindol-2-yl)-N-thiazol-2-yl-propionamide as outlined in Example 1, Step B) to provide N-(5-Chloro-thiazol-2-yl)-3-cyclohexyl-2-(1-oxo-1,3-dihydro-isoindol-2-yl) propionamide as a white solid in 59% yield: EI-HRMS m/e calcd for C20H22ClN3O2S (M+) 403.1121, found 403.1124.