Borane → (3-Fluoro-1,2-phenylene)dimethanol

온도

0 °C

To a stirred solution of borane.tetrahydrofuran complex (50 mL of 1.5 M solution in tetrahydrofuran/diethyl ether) cooled to 0° C. under argon was added a solution of 3-fluorophthalic acid (4.51 g; 24.0 mmol) in tetrahydrofuran (40 mL) dropwise over a 15 minute period. At the end of the addition, the mixture was allowed to stir for 2 h at 0° C. The mixture was allowed to warm to room temperature and then refluxed for 20 h. The mixture was allowed to cool to room temperature, quenched with methanol (30 mL) and concentrated in vacuo. The residue was taken up into ethyl acetate (150 mL), washed with saturated sodium bicarbonate solution. The aqueous layer was further extracted with ethyl acetate (2×125 mL) and the combined extracts were washed with brine solution. The organic extract was dried (sodium sulfate), filtered and concentrated in vacuo to give 3.73 g (99%) of 3-fluoro-1,2-di-(hydroxymethyl) benzene as a white solid: ES-LRMS calcd for C8H8FO2 (M+−1) 155, found 155.

1. additionAt the end of the addition
2. temperatureto warm to room temperature
3. temperaturerefluxed for 20 h
4. temperatureto cool to room temperature
5. customquenched with methanol (30 mL)
6. concentrationconcentrated in vacuo
7. washwashed with saturated sodium bicarbonate solution
8. extractionThe aqueous layer was further extracted with ethyl acetate (2×125 mL)
9. washthe combined extracts were washed with brine solution
10. extractionThe organic extract
11. dry with materialwas dried (sodium sulfate)
12. filtrationfiltered
13. concentrationconcentrated in vacuo

ORD 기록

ord-d2664d14baba4f3c85dd4e0375305321

출처 데이터셋

uspto-grants-2002_11

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US06482951B2