反应详情

BOP coupling of 3-Cyclopentyl-2-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionic acid (prepared in Example 1, Step A; 277 mg; 1.0 mmol) and 2-amino-5-chlorothiazole hydrochloride (397 mg; 2.30 mmol) in a manner similar to that used for the preparation of (S)-3-cyclohexyl-2-(1-oxo-1,3-dihydro-isoindol-2-yl)-N-thiazol-2-yl-propionamide as outlined in Example 1, Step B) provided after Flash chromatography (Biotage 40M eluent: 20% ethyl acetate/hexanes) 290 mg (74%) of N-(5-Chloro-thiazol-2-yl)-3-cyclopentyl-2-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide as a light yellow solid: EI-HRMS m/e calcd for C19H21N3O2S (M+) 389.0965, found 389.0966.