反应详情

A solution of phthalic dicarboxaldehyde (349 mg; 2.60 mmol) and 2-Amino-3-cyclooctyl-propionic acid (500 mg; 2.51 mmol) in acetonitrile (20 mL) was heated to reflux for 3 h. The mixture was then hot filtered to remove insoluble material and then allowed to cool to room temperature and then further cooled to 0° C. The solid was filtered off, rinsed with cold acetonitrile and air dried to give 480 mg (62%) of 3-Cyclooctyl-2-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionic acid as a white solid: EI-HRMS m/e calcd for C19H25NO3 (M+) 315.1834, found 315.1840.

1. temperatureto reflux for 3 h
2. filtrationThe mixture was then hot filtered
3. customto remove insoluble material
4. temperaturefurther cooled to 0° C
5. filtrationThe solid was filtered off
6. washrinsed with cold acetonitrile and air
7. customdried