Water → HCID 18398496, compound

Participants

Reaction Steps

This ketone is dissolved in trifluoro acetic acid and an excess of triethylsilane is added. After completion of the reaction, the mixture is poured into the 10-fold amount of water and extracted with dichloromethane. The combined dichloromethane extracts are washed as described above and dried afterwards. After removing of the solvent by distillation and chromatographic cleaning (silica gel; dichloromethane/heptane; gradient, starting with 1:1) 6-bromo-4-fluoro-2-octyl-indane is obtained.

Provenance & Evidence