Allyl bromide → HCID 12052162, compound

Participants

Reaction Steps

To a suspension of 4-phenylphthalazine-1-thiol (Example 1B) (238 mg, 1 mmol) in ethanol (40 ml) is added aqueous KOH (1 molar, 1 ml). After 10 minutes, allylbromide (0.1 ml, 1 mmol) is added, and the mixture is stirred at room temperature for 4 days. After the solvent is evaporated, the residue is extracted with CH2Cl2. The organic phase is evaporated and the residue is stirred with isopropyl ether. Filtration gives the pure title compound, which is recrystallized from ethanol (130 mg). (R1=vinyl, R2=phenyl, A=benzene, Y1=CH2, m=0, n=1, p=0, q=0).

Provenance & Evidence