Potassium Hydroxide → HCID 6992145, compound

HRID 1018928Notes

Reaction equation

HRID 1018928 reaction equation
[C:1]1([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([SH:17])=[N:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+].[Cl:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[CH2:24]Br>C(O)C>[Cl:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[CH2:24][S:17][C:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[N:8][N:9]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 698381-(Bromomethyl)-3-chlorobenzeneHCID 178527942HCID 178527942, compound

Product 1

HCID 6992145HCID 6992145, compoundYield 11%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of 4-phenylphthalazine-1-thiol (1 mmol; from Example 1B) in ethanol (20 ml) is added aqueous KOH (1 molar;1 ml), and the mixture is stirred for 10 minutes to give a clear solution. 3-Chlorobenzylbromide (0.13 ml, 1 mmol) is added at room temperature, and the solution is stirred overnight. Work-up yields the title compound as a white solid (40 mg).

Workup

  1. customto give a clear solution
  2. stirringthe solution is stirred overnight

Sources & evidence

ORD record
ord-6a6719ee1f804b81b421ccdadfce1464
Source dataset
uspto-grants-2002_11
Patent number
US06486158B1

Reaction notes

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