Hydrazine → HCID 178518902, compound

HRID 1018934Notes

Reaction equation

HRID 1018934 reaction equation
[NH2:1][NH2:2].Cl.[F:4][C:5]1[C:6]([C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=2)=O)=[C:7]([C:11]([F:14])=[CH:12][CH:13]=1)[C:8](O)=[O:9]>C(O)C>[F:4][C:5]1[CH:13]=[CH:12][C:11]([F:14])=[C:7]2[C:6]=1[C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)=[N:1][N:2]=[C:8]2[OH:9]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 70157926HCID 70157926, compound

Product 1

HCID 178518902HCID 178518902, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 3M-solution of hydrazine (60 mmol) in ethanol is added to a solution of crude 3,6-difluoro-2-(2-pyridylcarbonyl)benzoic acid hydrochloride (20 mmol), and the mixture is stirred at room temperature for 5 hours. Precipitation yields 5,8-difluoro-4-(2-pyridyl)-1-phthalazinol.

Workup

  1. customPrecipitation

Sources & evidence

ORD record
ord-e127a769aad74f78950a321914db80ec
Source dataset
uspto-grants-2002_11
Patent number
US06486158B1

Reaction notes

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