Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 18399624 | HCID 18399624 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 18399620 | HCID 18399620 | 69.2% |
Reaction Steps
A mixture of 0.70 g of Compound 4A, 5.6 mL of dioxane and 8.4 mL of 9N hydrochloric acid was stirred at reflux for 75 minutes. After cooling to 20-25° C., the precipitated solid was filtered, washed with dioxane/water 1:1.5 and water to afford 0.46 g of the title compound as a grey solid melting at 249-251° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06486163B1 |
|---|
| Source dataset | uspto-grants-2002_11 |
|---|
| ORD ID | ord-f3030061f66f4320ab2faf3deb80eea0 |
|---|
| Source note | uspto-grants-2002_11 |
|---|
