Triphenylphosphine → HCID 18374456, compound

Participants

Reaction Steps

To the product of Step 1 (680 mg, 2 mmol) in toluene (10 mL)—H2O (3 mL)—n Propanol (3 mL) were added 4-hydroxymethyl phenyl boronic acid (607 mg, 4 mmol), tris(dibenzylidene acetone)dipalladium (92 mg, 0.1 mmol), triphenylphosphine (209 mg, 0.8 mmol) and EtNH (175 mg, 2.4 mmol). After a period of 18 h at 90° C., the reaction mixture was partionned between EtOAc and H2O. The organic phase was separated, dried over NaSO4, filtered and evaporated under reduced pressure. The title compound was obtained after flash chromatography (446 mg, 69%).

Provenance & Evidence