Diethylamine → HCID 18398694, compound

Participants

Reaction Steps

To a compound of Step 1 (0.200 g, 0.588 mmol) in toluene (5 mL)—H2O (1.5 mL)-n-propanol (5 mL) were added 3-methyl phenyl boronic acid (0.158 g, 1.17 mmol), tris(dibenzylidene acetone)dipalladium (0.030 g), triphenylphosphine (0.123 g) and Et2NH (0.083 mL). After a period of 18 h at 80° C., the reaction mixture was partionned between EtOAc and H2O. The organic phase was separated, dried over Na2SO4, filtered and evaporated under reduced pressure. The title compound was obtained after flash chromatography (0.122 g).

Provenance & Evidence