Triethylamine → HCID 18398676, compound

Participants

Reaction Conditions

Reaction Steps

To a degassed solution of 6,8-dibromo-2-methylquinoline (3.01 g, 10 mmol, prepared according to Song et al. J. Heterocyclic Chem. 1993, 39, 17.), diethylphosphite (1.65 g, 12 mmol) and Et3N (1.21 g, 12 mmol) in toluene (3 mL) was added Pd(OAc)2 (224.5 mg, 1 mmol). The mixture was degassed and Ph3P (1.049 g, 4 mmol) was added. The mixture was heated to 100° C. for 7 h, cooled, diluted with EtOAc (200 mL) and filtered through celite. The filtrate was concentrated in vacuo. The residue was purified by chromatography on silica gel to give 475 mg (13%) of diethyl 6-bromo-2-methyl-8-quinolylphosphonate and 150 mg (4%) of diethyl 8-bromo-2-methyl-6-quinolylphosphonate.

Provenance & Evidence