Tetrahydrofuran → HCID 18398699, compound

Participants

Reaction Steps

To a solution of diethyl 6-bromo-2-formyl-8-quinolylphosphonate (293 mg, 0.78 mmol) in toluene (6 mL) at −10° C. was added a 2M solution of isobutylmagnesium bromide in THF (1.59 mL, 3.12 mmol). The mixture was stirred at −10° C. to −5° C. for 2 h. Aqueous NH4CL was added and the mixture was extracted with EtOAc. The organic extracts were washed with brine, dried (anhyd. MgSO4) and concentrated in vacuo. The residue was purified by chromatography on silica gel to give 179 mg (53%) of the title compound

Provenance & Evidence