Chloromethyl Methyl Ether → HCID 18398686, compound

Participants

Reaction Steps

To a solution of diethyl 6-bromo-2-(1-hydroxy-3-methylbutyl)-8-quinolylphosphonate (219 mg, 0.51 mmol) (Example 19, step 3) in THF (2 mL) at 0° C. was added NaH (40 mg, 1.02 mmol, 60% in oil). To the resulting green suspension was added chloromethyl methyl ether (82 mg, 1.02 mmol). The mixture was stirred at r.t. for 1.5 h, Aqueous NH4Cl was added and the mixture was extracted with EtOAc. The organic extracts were washed with brine, dried (anhyd. MgSO4) and concentrated in vacuo. The residue was purified by chromatography on silica gel to give 170 mg (70%) of the title compound.

Provenance & Evidence