反应详情

To a solution of 4′-methoxy-4-methylbiphenyl (10.5 g, 53 mmol) in CH2Cl2 (300 mL) at 0° C. was added a solution of 1M BBr3 in CH2Cl2 (65 mL, 65 mmol). The mixture was slowly warmed to r.t. and stirred overnight. After cooling to 0° C. again, the mixture was quenched with H2O. The CH2Cl2 layer was separated, washed with H2O, dried (MgSO4) and concentrated to give the title compound as a white solid (9.5 g, 97% yield).

1. temperatureAfter cooling to 0° C. again
2. customthe mixture was quenched with H2O
3. customThe CH2Cl2 layer was separated
4. washwashed with H2O
5. dry with materialdried (MgSO4)
6. concentrationconcentrated