1,2,3,4-Tetrahydroisoquinoline → HCID 9905998, compound

Participants

Reaction Steps

1,2,3,4-Tetrahydroisoquinoline, n-BuLi, and 2-(3-chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane were allowed to react under conditions analogous to Example 1, Method C. Flash chromatographic purification provided 4A (16% yield) as a yellow oil. 1H NMR(300 MHz, CDCl3, δ): 7.44-7.39 (m, 2H), 7.15-6.98 (m, 6H), 4.08-3.96 (m, 2H), 3.83-3.71 (m, 2H), 3.57 (s, 2H), 2.87 (t, 2H, J=6 Hz), 2.67 (t, 2H, J=6 Hz), 2.47 (t, 2H, J 7 Hz), 1.96-1.91 (m, 2H), 1.69-1.59 (m, 2H).

Provenance & Evidence