HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Chloride → 1-[4-(Tributylstannyl)-3,6-dihydropyridin-1(2H)-yl]ethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 1-Acetyl-4-hydroxy-4-tributylstannyl-piperidine | HCID 15636899 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-[4-(Tributylstannyl)-3,6-dihydropyridin-1(2H)-yl]ethan-1-one | HCID 15636896 | — |
Reaction Steps
Under an inert atmosphere, 1.3 equivalents of mesyl chloride in 15 ml of dichloromethane are added dropwise to a solution of 0.16 mmol of the compound obtained in Step A and 2.8 equivalents of triethylamine in 1 litre of dichloromethane at 0° C. After stirring the mixture at ambient temperature for 4 days, a saturated aqueous solution of NaCl is added. After extraction, drying, filtration and concentration of the organic phase under reduced pressure, chromatography of the residue on silica gel (dichloromethane/ethanol: 97/3) enables the expected product to be isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06486171B2 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-0fc30f5eb56a4be7875caa7ca78b2758 |
| Source note | uspto-grants-2002_11 |