1-Benzyl-4-(N-Boc-amino)piperidine → 4-(N-Boc-amino)piperidine

HRID 1018995Notes

Reaction equation

HRID 1018995 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[NH:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15](=[O:21])[O:16][C:17]([CH3:19])([CH3:18])[CH3:20])[CH2:12][CH2:13]1

Participants

4

Reactant 1

HCID 44386181-Benzyl-4-(N-Boc-amino)piperidine

Product 1

HCID 7238334-(N-Boc-amino)piperidine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

6 g of Pd/C (10%) are added to a solution of 0.224 mol of tert-butyl 1-benzyl-4-piperidinylcarbamate in 800 ml of anhydrous ethanol. The reaction mixture is placed under a hydrogen pressure of 4 bars, at 50° C., for 48 hours, and then filtered over Celite and concentrated under reduced pressure, enabling the expected product to be isolated.

Workup

  1. filtrationfiltered over Celite
  2. concentrationconcentrated under reduced pressure
  3. customto be isolated

Sources & evidence

ORD record
ord-6548b59f40dd43c0a2e75c213bd1e016
Source dataset
uspto-grants-2002_11
Patent number
US06486171B2

Reaction notes

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