1-Benzylpiperazine → HCID 18399759, compound

HRID 1018996Notes

Reaction equation

HRID 1018996 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([CH2:11][C:12]#[N:13])[CH:5]=[CH:4][N:3]=1.[CH2:14]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH2:14]([N:21]1[CH2:26][CH2:25][N:24]([C:2]2[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([CH2:11][C:12]#[N:13])[CH:5]=[CH:4][N:3]=2)[CH2:23][CH2:22]1)[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 759941-BenzylpiperazineHCID 10607992HCID 10607992, compound

Product 1

HCID 18399759HCID 18399759, compound

Procedure

A solution of 15 g of (2-chloro-3-nitropyridin-4-yl)acetonitrile and 1.1 equivalents of N-benzyl-piperazine is heated for 10 minutes, at 80° C., under a stream of argon, and then concentrated under reduced pressure. Chromatography on silica gel (dichloromethane/methanol: 100/0 to 95/5) enables the expected product to be isolated.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customto be isolated

Sources & evidence

ORD record
ord-229a22003bc84d34a1034a431f9b8fc4
Source dataset
uspto-grants-2002_11
Patent number
US06486171B2

Reaction notes

Loading…