Sodium borohydride → HCID 18399767, compound

HRID 1019008Notes

Reaction equation

HRID 1019008 reaction equation
[NH:1]1[C:9]2[CH:8]=[CH:7][N:6]=[C:5]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]4[C:26]5[C:21](=[CH:22][CH:23]=[C:24]([CH:27]=[O:28])[CH:25]=5)[NH:20][CH:19]=4)[CH2:12][CH2:11]3)[C:4]=2[CH:3]=[CH:2]1.[BH4-].[Na+]>C(O)C.O>[OH:28][CH2:27][C:24]1[CH:25]=[C:26]2[C:21](=[CH:22][CH:23]=1)[NH:20][CH:19]=[C:18]2[CH2:17][CH2:16][N:13]1[CH2:14][CH2:15][N:10]([C:5]2[C:4]3[CH:3]=[CH:2][NH:1][C:9]=3[CH:8]=[CH:7][N:6]=2)[CH2:11][CH2:12]1

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 18399730HCID 18399730, compound

Product 1

HCID 18399767HCID 18399767, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of 2 mmol of the compound obtained in Step 4 in 50 ml of ethanol is treated with 2.2 mmol of sodium borohydride for 24 hours. The solvent is evaporated off under reduced pressure and the residue obtained is taken up in water and then extracted with dichloromethane. The organic phase is dried and filtered and then concentrated under reduced pressure, enabling the expected product to be obtained.

Workup

  1. customThe solvent is evaporated off under reduced pressure
  2. customthe residue obtained
  3. extractionextracted with dichloromethane
  4. customThe organic phase is dried
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure
  7. customto be obtained

Sources & evidence

ORD record
ord-7c488aecb43441de941df78eb15e2481
Source dataset
uspto-grants-2002_11
Patent number
US06486171B2

Reaction notes

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