Amlodipine → HCID 86758618, compound

Participants

Reaction Steps

Chloromethyl chloroformate (2.85 g, 22 mmol) is added to amlodipine (10.5 g, 20 mmol) and pyridine (1.6 g) in 300 ml chloroform cooled in an ice bath. The reaction mixture is stirred at room temperature for 16 h, washed with water, dried (anhydrous sodium sulfate) and concentrated under reduced pressure. The residue is dissolved in dimethylformamide (50 ml) containing the calcium salt of atorvastatin (10.75 g, 0.018 mol) and the reaction mixture is heated at 80° C. for 20 h. The dimethylformamide is removed in vacuo and the residue is triturated with chloroform-hexane to yield the title compound the title compound of Example Two.

Provenance & Evidence