Sodium Hydroxide → 5-[3-(Imidazol-1-yl)prop-1-en-1-yl]-2-(4-fluorophenethyl)benzoic acid

Participants

Reaction Steps

Sodium hydroxide (0.8 g, 20 mmol) in distilled water (3 ml) was added to a solution of methyl 5-[3-(imidazol-1-yl)prop-1-en-1-yl]-2-(4-fluorophenethyl)benzoate (E and Z isomers) (2.4 g;.6.6 mmol) in methanol (30 ml). The mixture was refluxed for 6 hours. After evaporation and acidification with 12N HCl to pH 6, the residue was extracted with dichloromethane and evaporated to dryness to give 5-[3-(imidazol-1-yl)prop-1-en-1-yl]-2-(4-fluorophenethyl)benzoic acid (mixture of E and Z isomers).

Provenance & Evidence