Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Carbon tetrabromide → Methyl 2-(4-fluorophenyl)-4-(3-bromoprop-1-en-1-yl)benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Carbon tetrabromide | HCID 11205 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | HCID 53969551 | HCID 53969551 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Methyl 2-(4-fluorophenyl)-4-(3-bromoprop-1-en-1-yl)benzoate | HCID 54112501 | — |
반응 단계
A solution of methyl 2-(4-fluorophenyl)-4-(3-hydroxyprop-1-en-1-yl)benzoate (17 g), triphenylphosphine (22.8 g; 87 mmol) and tetrabromomethane (28.8 g; 87 mmol) in dichloromethane (200 ml) was stirred at 0° C. for 1 hour. After filtration of the insoluble material and evaporation to dryness, the residue was purified by flash chromatography eluting with dichloromethanelpetroleum ether (30/70) to give methyl 2-(4-fluorophenyl)-4-(3-bromoprop-1-en-1-yl)benzoate as a mixture of E and Z isomers.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06486156B1 |
| 출처 데이터셋 | uspto-grants-2002_11 |
| ORD ID | ord-6934065b6821496c80c99c347f2c737e |
| 출처 메모 | uspto-grants-2002_11 |