1-Methylimidazole → HCID 18399515, compound

HRID 1019038Notes

Reaction equation

HRID 1019038 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:17]=[C:16]([CH:18]=[CH:19][CH2:20]Br)[CH:15]=[CH:14][C:9]=2[C:10]([O:12][CH3:13])=[O:11])=[CH:4][CH:3]=1.CN1C=CN=C1CC=CC1C=CC(C(OC)=O)=C(C2C=CC(F)=CC=2)C=1.[C:48]([N:67]1[CH:71]=[CH:70][N:69]=[CH:68]1)([C:61]1[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=1)([C:55]1[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=1)[C:49]1[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=1.CN1C=CN=C1>>[C:48]([N:67]1[CH:71]=[CH:70][N:69]=[C:68]1[CH2:20]/[CH:19]=[CH:18]/[C:16]1[CH:15]=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[CH:17]=1)([C:55]1[CH:56]=[CH:57][CH:58]=[CH:59][CH:60]=1)([C:61]1[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=1)[C:49]1[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=1

Participants

5

Reactant 4

HCID 13901-MethylimidazoleHCID 618231DechloroclotrimazoleHCID 54112501Methyl 2-(4-fluorophenyl)-4-(3-bromoprop-1-en-1-yl)benzoateHCID 54337160Methyl 4-[3-(1-methylimidazol-2-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoate

Product 1

HCID 18399515HCID 18399515, compound

Procedure

Methyl 4-[(E)-3-(1-tritylimidazol-2-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoate was prepared from methyl 2-(4-fluorophenyl)-4-(3-bromoprop-1-en-1-yl)benzoate using a similar method to that described for methyl 4-[3-(1-methylimidazol-2-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoate in Example 21, but using N-tritylimidazole in replacement of N-methylimidazole.

Sources & evidence

ORD record
ord-f7ccead4387646d7b34303b131575e2f
Source dataset
uspto-grants-2002_11
Patent number
US06486156B1

Reaction notes

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