Sodium Hydroxide → HCID 18399504, compound

Participants

Reaction Steps

A solution of methyl 4-[(E)-3-(imidazol-1-yl)prop-1-en-1-yl]-2-(2,4-difluorophenyl)benzoate (0.9 g; 2.54 mmol) and 2N sodium hydroxide solution (3.8 ml) in methanol was heated at reflux for 7 hours. After evaporation of the solvent and neutralisation to pH 6.5 with 6N HCl, the residue was purified on reverse phase silica eluting with methanol/ammonium carbonate buffer (2 g/l, pH 7) (50/50) to give 4-[(E)-3-(imidazol-1-yl)prop-1-en-1-yl]-2-(2,4-difluorophenyl)benzoic acid after freeze-drying. Yield: 49%.

Provenance & Evidence