HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Iodo-1-methyl-1H-imidazole → Methyl 4-[3-(1-methylimidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Iodo-1-methyl-1H-imidazole | HCID 1277668 | — |
| Reactant | methyl 4-[(E)-3-(1-tritylimidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoate | HCID 18399521 | — |
| Reactant | Methyl 2-(4-fluorophenyl)-4-(3-bromoprop-1-en-1-yl)benzoate | HCID 54112501 | — |
| Product | Methyl 4-[3-(1-methylimidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoate | HCID 54550986 | 59% |
Reaction Steps
Methyl 4-[3-(1-methylimidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoate was prepared from methyl 4-(3-bromoprop-1-en-1-yl)-2-(4-fluorophenyl)benzoate and 5-iodo-1-methyl-imidazole using a similar method to that described for methyl 4-[(E)-3-(1-tritylimidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoate in Example 37.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06486156B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-4470a48e7c544fc79fc9e1e3200594a1 |
| Source note | uspto-grants-2002_11 |