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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1019047Generated: October 31, 2026

4-[(E)-3-(imidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoic acid → 4-[3-(1-Methylimidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoic acid

https://huagongshe.com/reaction/1019047

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-[(E)-3-(imidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoic acidHCID 18399508—
ReactantMethyl 4-[3-(1-methylimidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoateHCID 54550986—
Product4-[3-(1-Methylimidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoic acidHCID 53878690—

Reaction Steps

4-[3-(1-Methylimidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoic acid was prepared from methyl 4-[3-(1-methylimidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoate using a similar method to that described for 4-[(E)-3-(imidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoic acid in Example 37.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06486156B1
Source datasetuspto-grants-2002_11
ORD IDord-e12dfe9f7c694da68536eb7f3db3f989
Source noteuspto-grants-2002_11