反应详情

A solution of methyl 4-[3-(1-benzylimidazol-2-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoate (3 g; 7 mmol), sodium hydroxide (0.8 g; 20 mmol) and distilled water (5 ml) in methanol (50 ml) was refluxed for 4 hours. After evaporation to dryness and acidification to pH 6 with 6N HCl, the resulting solid was triturated with water and ether to give 4-[3-(1-benzylimidazol-2-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoic acid as a mixture of E and Z isomers.

1. temperaturewas refluxed for 4 hours
2. customAfter evaporation to dryness and acidification to pH 6 with 6N HCl
3. customthe resulting solid was triturated with water and ether