Trifluoroacetic acid → HCID 9825135, compound

Participants

Reaction Steps

A solution of tert-butyl (2S)-2-{4-[(E)-3-(imidazol-1-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzamido}-4-methylsulfanylbutyrate (0.2 g; 0.4 mmol) in dichloromethane (2 ml) was treated at 0° C. with TFA (2 ml). The mixture was allowed to warm to ambient temperature and stirred for 1 hour. After evaporation of the solvent, the residue was taken up with distilled water (5 ml); the pH was adjusted to 6 with NH4OH and the solution was purified on reverse phase silica eluting with methanol/ammonium carbonate buffer (2 g/l; pH 7) (40/60) to give the title compound after freeze-drying. Yield: 40%

Provenance & Evidence