N-bromobutanimide → HCID 18399512, compound

Participants

Reaction Steps

A solution of methyl 1-[5-methyl-3-(4-fluorophenyl)-thien-2-yl]methanoate (12.9 g; 0.05 mol), N-bromosuccinimide (11.02 g; 0.0619 mol) and 2-2′-azobisisobutyronitrile (0.339 g; 2.06 mmol) in Cl4 (300 ml) was reflux under argon atmosphere for 90 minutes under UV irradiation. After filtration of the precipitate, the filtrate was evaporated to dryness to give methyl 1-[5-bromomethyl-3-(4-fluorophenyl)-thien-2-yl]methanoate as a solid which was used in the next step without purification.

Provenance & Evidence