Lithium Hydroxide → 4-(4-methoxybenzyloxy) benzoic acid

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 4-(4-methoxybenzyloxy)benzoate (12.2 g, 44.8 mmole) in 50 ml 1,4-dioxane was added a solution of lithium hydroxide (2.15 g, 89.6 mmole) and the mixture was stirred overnight at 60° C. The mixture was evaporated under reduced pressure and 5% acetic acid was added. The product was filtered, washed with water and dried. Yield: 10.1 g=87%

Provenance & Evidence