HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-chloronicotinate → Methyl 2-[[4-(2-methyl-1-oxopropyl)phenyl]amino]-3-pyridinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-chloronicotinate | HCID 819931 | — |
| Reactant | 1-(4-Aminophenyl)-2-methylpropan-1-one | HCID 5151044 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 2-Methoxyethanol | HCID 8019 | — |
| Product | Methyl 2-[[4-(2-methyl-1-oxopropyl)phenyl]amino]-3-pyridinecarboxylate | HCID 22603050 | 118.9% |
Reaction Steps
A mixture of 1-(4-aminophenyl)-2-methyl-1-propanone (0.0637 mol) and methyl 2-chloro-3-pyridinecarboxylate (0.0637 mol) in 2-methoxyethanol (200 ml) was stirred and refluxed for 90 hours. The mixture was taken up in water and EtOAc and extracted with EtOAc. The organic layer was separated, dried, filtered and the solvent was evaporated, yielding 22.6 g of methyl 2[[4-(2-methyl-1-oxopropyl)phenyl]amino]-3-pyridinecarboxylate (interm. 20).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06486187B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-8b32521dad5e43bf90b65ccb18cb8cfd |
| Source note | uspto-grants-2002_11 |