Dimethyl Ether → HCID 178430922, compound

HRID 1019079Notes

Reaction equation

HRID 1019079 reaction equation
N1(N[C:7]2[NH:8][C:9]3[C:15]([CH3:16])=[CH:14][CH:13]=[C:12]([O:17]C)[C:10]=3[N:11]=2)CCN=C1.C(C1C2NC=NC=2C(C)=CC=1[NH:31][N:32]1[CH2:36][CH2:35][N:34]=[CH:33]1)C.COC.Cl.[NH+]1C=CC=CC=1>>[OH:17][C:12]1[C:10]2[N:11]=[CH:7][NH:8][C:9]=2[C:15]([CH3:16])=[C:14]([NH:31][N:32]2[CH2:36][CH2:35][N:34]=[CH:33]2)[CH:13]=1

Participants

5

Reactant 4

HCID 8254Dimethyl EtherHCID 21584435Pyridinium hydrochlorideHCID 69829891HCID 69829891, compoundHCID 178489910HCID 178489910, compound

Product 1

HCID 178430922HCID 178430922, compound

Procedure

(2-imidazolinylamino)-7-methoxy-4-methylbenzimidazole is made in the same manner as 4-ethyl-5-(2-imidazolinylamino)-7-methylbenzimidazole except that 2-methoxy-5-methylacetanilide is used instead of 3-ethyl-6-methylacetanilide (see Example 2). Cleavage of the methyl ether is achieved with pyridinium hydrochloride to afford 7-hydroxy-5-(2-imidazolinylamino)-4-methylbenzimidazole.

Sources & evidence

ORD record
ord-b760114292d14d2a94328c04b6f81200
Source dataset
uspto-grants-2002_11
Patent number
US06486190B1

Reaction notes

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