HCID 18400133, compound → HCID 178432209, compound

Participants

Reaction Steps

A mixture of N-(1-t-butoxycarbonyl-2,4-dimethyl-5-benzimidazolyl)-N′-2-aminoethylthiourea (1.33 g, 3.66 mmol) and mercuric acetate (1.45 g, 4.54 mmol) in methanol (150 mL) is stirred at room temperature for 1 hour. The resulting black mixture is filtered on Celite with a methanol wash of the solids. The filtrate is rotary evaporated and the residue is purified by flash chromatography on a short pad of silica gel, eluting with 10% methanol/chloroform containing 1% of ammonium hydroxide. The product-containing fractions are collected and rotary evaporated to afford 2,4-dimethyl-5-(2-imidazolinylamino)benzimidazole as a white solid.

Provenance & Evidence