Cyanogen Bromide → HCID 178422334, compound

HRID 1019093Notes

Reaction equation

HRID 1019093 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([N+:9]([O-:11])=[O:10])=[C:4]([CH3:12])[C:3]=1[NH2:13].[N:14]#[C:15]Br>CO>[NH2:14][C:15]1[NH:13][C:3]2[C:4]([CH3:12])=[C:5]([N+:9]([O-:11])=[O:10])[C:6]([CH3:8])=[CH:7][C:2]=2[N:1]=1

Participants

4

Reactant 2

HCID 10476Cyanogen BromideHCID 18400131HCID 18400131, compound

Product 1

HCID 178422334HCID 178422334, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 1,2-diamino-3,5-dimethyl-4-nitrobenzene (0.87 g, 4.83 mmol) and cyanogen bromide (0.87 g, 7.73 mmol) in methanol (50 mL) is stirred at room temperature for 16 hours. The mixture is rotary evaporated to afford 2-amino-4,6-dimethyl-5-nitrobenzimidazole. The product is used in the next step without further purification.

Workup

  1. customThe mixture is rotary evaporated

Sources & evidence

ORD record
ord-2121f0f7f42245fc8690c0df3ca21d14
Source dataset
uspto-grants-2002_11
Patent number
US06486190B1

Reaction notes

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