反应详情

Combine 6-aminohexanoic acid (6-aminocaproic acid) (8.0 g, 60 mmol) and water (100 mL). Add sodium carbonate (6.84 g, 64 mmol) and N-carbethoxyphthalimide (14.0 g, 64 mmol). After 1.5 hours, extract the reaction mixture with ethyl acetate (100 mL). Cool the aqueous layer in an ice bath and acidify using concentrated hydrochloric acid to give a solid. Collect the solid by filtration, rinse with water, and dry to give 6-phthalimidohexanoic acid (12.7 g, 80% yield).

1. extractionextract the reaction mixture with ethyl acetate (100 mL)
2. temperatureCool the aqueous layer in an ice bath
3. customto give a solid
4. customCollect the solid
5. filtrationby filtration
6. washrinse with water
7. customdry