HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl 4-fluoro-2-nitrophenylmalonate → 2-(4-Fluoro-2-nitrophenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl 4-fluoro-2-nitrophenylmalonate | HCID 9838325 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 2-(4-Fluoro-2-nitrophenyl)acetic acid | HCID 10750492 | 89.9% |
Reaction Steps
Dimethyl 4-fluoro-2-nitrophenylmalonate (5.0 g) was refluxed in 20 mL of 6N hydrochloric acid for 24 hours. The reaction was cooled and the white solid collected by vacuum filtration, washed with water and dried to give 3.3 g (87% yield) of 4-fluoro-2-nitrophenylacetic acid, Rf 0.6 on thin layer chromatography (ethyl acetate:hexane 1:2, silica gel).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06486185B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-ceb1287387c64418951e359f8ff7e8c7 |
| Source note | uspto-grants-2002_11 |