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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1019159Generated: October 31, 2026

Oxindole → HCID 5353975, compound

https://huagongshe.com/reaction/1019159

Reaction equation

Participants

RoleNameHCIDCharge
ReactantOxindoleHCID 321710—
ReactantHCID 10560772HCID 10560772—
CatalystPiperidineHCID 8082—
SolventEthanolHCID 702—
ProductHCID 5353975HCID 535397565%

Reaction Conditions

Temperature90 °C

Reaction Steps

A mixture of 133.15 mg (1 mmol) of 2-indolinone, 228.3 mg (1.2 mmol) of 4-(1-formylpiperazin-4-yl)benzaldehyde and 3 drops of piperidine in 2 ml of ethanol was stirred at 90° C. for 5 hr. After cooling, the precipitate was filtered, washed with cold ethanol and dried to yield 199.5 mg (65%) of the title compound as a yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06486185B1
Source datasetuspto-grants-2002_11
ORD IDord-6126f15be44946d8acad473183f8ad88
Source noteuspto-grants-2002_11