Water → HCID 18400249, compound

Participants

Reaction Steps

Compound 1 (25.62 g, 103.2 mmol) was dissolved in CH3CN (370 mL) at room temperature under nitrogen. H2O (15.5 mL) and a 57% aqueous solution of HI (14.7 mL) were added. The reaction solution was stirred at room temperature for 1 hour, and then was diluted with EtOAc (1000 mL), washed with H2O (400 mL), 0.25N Na2S2O3 (400 mL), H2O (400 mL), and saturated aqueous NaCl (400 mL), dried over Na2SO4, filtered, evaporated, and dried under vacuum to afford 24.31 g (100%) of Compound 2 as a yellow oil, which was used without further purification. The following values were obtained by nuclear magnetic resonance spectroscopy:

Provenance & Evidence