HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-(4-Bromobenzyl)-5-chloro-2-phenyl-3H-imidazole-4-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Bromobenzyl bromide | HCID 68527 | — |
| Reactant | HCID 178520008 | HCID 178520008 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(4-Bromobenzyl)-5-chloro-2-phenyl-3H-imidazole-4-carbaldehyde | HCID 10915772 | 71.5% |
Reaction Steps
3.0 g of 4-chloro-5-formyl-2-phenylimidazole (Chem. Pharm. Bull. 1976, 24(5), 960), 7.0 g of 4-bromobenzyl bromide and 11.7 g of K2CO3 are stirred at RT for 20 h in 200 ml of DMF. The reaction mixture is then poured onto 500 ml of water, and the precipitate is filtered off with suction and chromatographed on silica gel using DIP. 3.9 g of an amorphous foam are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06486189B2 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-e69139195873471f8cbfb4b28e5fc809 |
| Source note | uspto-grants-2002_11 |